In a bowl, add the eggs, hot sauce, garlic powder, onion powder, yellow mustard, and salt. Mix thoroughly until well blended
Cut each tilapia fillet into four portions and place them in the marinade. Ensure the fish is coated well and let it rest for at least 15 to 30 minutes
Next, in a shallow tray, combine all-purpose flour, panko bread crumbs, cornmeal, garlic powder, onion powder, black pepper, paprika or chili powder, Italian seasoning, and salt
Coat the marinated fish fillets evenly with the breading mixture. Press the fish fillets gently while coating them to ensure an even and thorough coating
In a wide pan, heat oil over medium-high heat. Carefully place the breaded fish fillets in the pan, making sure not to overcrowd it
Fry the fish for approximately 4 to 5 minutes on each side, or until they turn golden brown
Using a slotted spoon, remove the fried fish from the oil and let the excess oil drain on a paper towel
Serve the crispy Fish Fry with lemon wedges and dipping sauces or other sides of your choice